There is a lump in the thigh muscle, and the treatment varies according to the nature of the lump. A. Intermuscular hematoma, which is a large localized mass caused by bleeding inside the muscle after a trauma or fall. If the hematoma is large in size and has obvious compression symptoms on the limb, it is necessary to perform hematoma aspiration under the guidance of color ultrasound or directly perform surgery to explore the hematoma and clear the drainage to improve the compression symptoms of the hematoma. Secondly, if it is muscle invasion caused by thigh bone tumor, causing intra-muscular mass. In this case, the patient’s prognosis is poor, so it is necessary to perform bone tumor resection and muscle mass clearance as soon as possible to prolong the patient’s life as much as possible, and if necessary, it is necessary to combine local radiotherapy and chemotherapy to inhibit the recurrence of tumor after surgery.