Age-related degenerative changes of the knee often result in pain, joint swelling, joint interlocking, knee weakness and joint dysfunction. 1. Pain: Elderly patients will have knee pain, which can be alleviated at rest and aggravated after activities, and it is usually more difficult for patients to go up and down the stairs, using the healthy leg to exert force. When the patient has a joint sprain, overwork, cold, etc., the pain will be aggravated, and in severe cases, it will not only affect the activities of the legs, but also affect the sleep. 2. Joint swelling: when degenerative changes in the knee occur in elderly patients with synovial hyperplasia and fluid accumulation in the joints, there will be persistent joint swelling. 3. Joint interlocking: the elderly will be in the process of exercise, the knee joints like stuck in general, unable to move, you need to try to flexion and extension of the joints and rocking, until you hear the joints ringing, and then you can resume activities. 4. Knee weakness: the elderly may experience leg weakness when walking, easy to fall phenomenon, and this stage of the patient may also be accompanied by severe pain in the joints. Some patients may also be due to a long time to maintain a certain state of static joints, and then again activities can not flexion and extension, severe pain. Only after gradual activity, the knee joint can flex and extend normally. 5. Joint dysfunction: patients may have synovial membrane hyperplasia, bone redundancy formation, cartilage destruction, which may also lead to the knee joint can not be bent, and some patients may even affect defecation. And patients may also have joint coarseness and deformity. It is recommended that patients with degenerative knee disease pay more attention to their own care so as not to aggravate the symptoms, and seek medical treatment if necessary.