When skull defect occurs, it is obvious that the patient’s appearance will be seriously damaged, some will be collapsed, some will be bulged, no matter which one, it will make the patient become less confident and produce a deep sense of inferiority; in addition, without the protection of the skull, the brain tissue will be easily damaged, which will easily lead to abnormal cerebrospinal fluid circulation and blood supply disorder and other problems. Therefore, once skull defect occurs, timely examination and treatment in regular hospitals is the key. There are many materials about skull repair surgery in medicine, such as plexiglass in the early stage, bone cement, titanium alloy in the later stage, and so on. However, after a series of clinical verification, these common materials have certain defects and patients will have various physical rejection reactions after surgery, so it is necessary to choose a safer material in order to achieve a better postoperative effect. The new PEEK material is safer, more advanced, harder, more flexible, and less prone to deformation. This PEEK material is a good insulator, stable, three-dimensional shaping, and has an extremely high degree of fit, making it a good choice for skull repair surgery.