SMA refers to spinal muscular atrophy, including type 1, type 2, type 3, type 4, etc. In terms of treatment, sodium nociceptin is given to improve the condition, strengthen nursing care, and regular rehabilitation therapy. 1. SMA type 1. At the onset of this disease, there may be progressive symmetrical weakness of the limbs, mainly proximal, with decreased muscle tone. The lower limbs are frog-legged, tongue muscle tremor, sucking weakness and so on. 2. SMA2 type. Symptoms of muscle weakness appear, the lower limbs are heavier than the upper limbs, and generally the facial and extraocular muscles are not involved. With the aggravation of the disease, cough weakness, dysphagia, joint contracture and other symptoms will appear. 3. SMA3 type. With ageing, there will be muscle weakness mainly in the proximal end, the lower limbs are heavier than the upper limbs, and when the condition worsens, there will be scoliosis and respiratory insufficiency gradually. 4. SMA4 type. Early motor development is normal, adults will gradually appear proximal weakness, slow progress. In terms of treatment, use sodium nociceptin, risperidone and other drugs to treat. Strengthen nursing care to avoid intrapulmonary infection, and should turn over and pat the back every day. Rehabilitation can be actively carried out in the early stage, including regular administration of physical factor therapy and correct use of orthotics. If SMA is diagnosed, it is recommended to seek medical treatment as early as possible and standardize the treatment under the guidance of professional physicians.