Glipizide and metformin are both commonly used in the treatment of diabetes, and the differences between them are as follows: First, the mechanism of action is different. Glipizide is an insulinotropic agent, which works by promoting insulin secretion. Metformin works by promoting peripheral utilization of glucose, promoting anaerobic enzymes and improving insulin resistance. Second, the effects are different. Glipizide works by promoting insulin secretion, so when the dose is too high or the history of irregular diet, hypoglycemic symptoms may occur, and in severe cases, hypoglycemic coma may occur. Metformin, when applied alone, does not cause hypoglycemia. Third, the effect on body weight, glipizide tablets work by promoting insulin, which has the effect of increasing body weight, so glipizide tablets can also cause weight gain. Metformin, on the other hand, can reduce body weight, so it is more suitable for obese type 2 diabetic patients, and can also be used for weight loss treatment for non-diabetic obese patients.