Standing up headache is mainly caused by the following reasons: first, postural hypotension, suddenly stand up body organs need to adapt, for the whole body blood pressure, but vasoconstriction to increase the supply of cerebral blood flow, if the usual cerebral vascular spasm, hypertension, hyperlipidemia, etc., there can be a temporary lack of cerebral blood supply, and the pain. Secondly, low cranial pressure caused by cerebrospinal fluid, especially patients who have had puncture, especially lumbar puncture, or patients who have had surgery with cerebrospinal fluid leakage, when standing, due to the pressure difference between the skull and the spinal cord, causing headache. Third, it may be related to the cervical spine, standing cervical spine is in the state of positional change, when the cervical spine is unstable there will be radiating pain, clinical life should also pay attention to, especially postural hypotension, to cause extensive attention, so as not to further aggravate the situation, to actively intervene in the antihypertensive treatment, to correct the body’s hyperlipidemia.