Pain in the little toe may be related to physiological factors, or it may be caused by trauma, onychomycosis, tinea pedis and other reasons. 1. Physiological factors: such as wearing shoes that are too thin and ill-fitting, or walking long distances within a short period of time, strenuous exercise, etc., may lead to prolonged friction and stimulation of the little toes, thus causing pain in the little toes. 2. Trauma: If the little toe is accidentally impacted by external forces, resulting in trauma to the little toe, resulting in local soft tissue injury or fracture, it may cause pain in the little toe, in addition to local bruising, swelling and other manifestations. 3. Inguinitis: usually due to ingrown nails, trimming nails or pulling out barbs and other factors, resulting in small toenail nail groove local infection, under the stimulation of inflammation, it may cause small toe pain, may also be accompanied by local redness and swelling, or even pus and other manifestations. 4. Tinea pedis: If the little toe area suffers from tinea pedis, due to the stimulation of fungal infection, it may cause little toe pain, itching, may also be accompanied by blisters, lesions and other manifestations. The possible causes of pain in the little toes are many, in the ability to exclude physiological factors, should be early to seek medical attention, improve the relevant examination, clear the cause of the disease, by the doctor’s guidance for targeted treatment.