Menstruation refers to menstruation, the menstruation is not clean for 15 days is called prolonged menstruation, it may be related to luteal insufficiency, endometrial hyperplasia, endometriosis and so on, you can consider oral progesterone, norethindrone tablets, medroxyprogesterone and other medications to treat it. 1. Luteal insufficiency: due to poor development of the corpus luteum, insufficient secretion of luteinizing hormone or premature degeneration of the corpus luteum, causing hormonal imbalance and leading to prolonged menstrual period. Oral progesterone, dydrogesterone and other medications can be considered. 2. Endometrial hyperplasia: when estrogen stimulates the endometrium for a large amount or a long period of time due to various reasons, the endometrium is prone to abnormal hyperplasia, resulting in prolonged menstrual periods. Patients with endometrial hyperplasia without atypical hyperplasia usually choose norethindrone tablets or progesterone. Megestrol is often used in patients with endometrial hyperplasia with atypical hyperplasia who need to preserve fertility. 3. Endometriosis: It may be due to reflux of menstrual blood, heredity, immunity and other factors, resulting in ectopic endometriosis outside the uterine cavity, causing prolonged menstrual periods, cycle disorders and small amount of vaginal bleeding. Oral medications such as medroxyprogesterone, mifepristone, and norethindrone can be considered, and if medication is not effective, surgery to remove the lesion can be an option. The above medications should be used under the guidance of a doctor. Prolonged periods can also be seen for other reasons. Follow the doctor’s instructions to carry out relevant examinations, with the help of the doctor to clarify the causes, and targeted treatment or therapy.