The enlarged lymph nodes of lung cancer may be due to the metastasis of lymph nodes. In this case, the choice of drug treatment should depend on what kind of lung cancer is a pathological type and what kind of molecular biological characteristics. Firstly, if the lung cancer is small cell lung cancer, the heaviest drug is the combination of chemotherapy with pegylated glycosides and platinum drugs, and oral drugs with temozolomide also have certain effect, but this is placed in the second line of treatment. Secondly, if it is one of the most common lung adenocarcinoma and there is a sensitive driver mutation, you can take the corresponding targeted drugs orally, such as gefitinib, exatinib or octreotinib. Then if the patient is a frequent smoker, the biggest possibility is squamous cell carcinoma, and drugs such as paclitaxel and gemcitabine can be applied. Finally, to summarize the use of drugs for enlarged lymph nodes in lung cancer, the main thing is to target the tumor itself, rather than just targeting a certain enlarged lymph node.