Nine-valent HPV vaccination is given to healthy women aged 16-26 years old, and three injections are given in the sequence of the 0th, 2nd, and 6th months, which can play a role in preventing more than 90% of cervical cancers. It will also play an active role in preventing vulvar cancer, vulvar warts and other lesions of the genitalia of the vulva. The nine-valent human papillomavirus vaccine is the most effective vaccine to prevent cervical cancer. Most women do not experience discomfort after the vaccination, but very few women may experience fever, itching and redness at the vaccination site, which require appropriate symptomatic treatment. Even after the HPV vaccination, women should pay attention to keep their vulva clean and hygienic, avoid high-risk behavior, and exercise appropriately to enhance their physical fitness.