Patients with thyroid disease can develop some degree of edema. Patients with hypothyroidism will develop significant edema, characterized by non-depressed, generalized edema, mostly in the eyelids, lower extremities, fingers, both feet and anterior thighs, all with mucous edema, such as anterior tibial mucous edema, all of which are considered edema due to hypothyroidism. Patients with abnormal thyroid function, serious ones such as developing hypothyroid heart disease or hyperthyroid heart disease, are prone to heart failure. Patients with heart failure will also have varying degrees of swelling, especially for patients with right heart failure, which will be dominated by swelling of the lower extremities. In patients with hypothyroidism, there is also a combination of renal insufficiency, and in patients with renal insufficiency, excessive protein loss outside the body will lead to varying degrees of hypoproteinemia, which will further deepen the swelling.