At present, there is an increasing conflict of donor shortage worldwide. Kidney transplantation in China mainly comes from cadaveric donor kidneys, but with more than 100,000 new uremic patients each year, cadaveric donor kidneys are far from meeting the needs. Relative donor kidney transplantation has the advantages of ideal mating, low incidence of rejection, short thermal ischemia and cooling ischemia time, low postoperative immunosuppressive dosage and relatively low surgical cost, and can be an alternative to dialysis for life support. However, it carries certain risks at the expense of a healthy person’s normal kidney, and a series of national laws and regulations have been introduced to regulate living donor kidney transplantation from relatives. Before a kidney donor decides to donate a kidney to your loved one, the following should be clear: 1. The law must be met: 18 years of age or older, have full civil capacity, be the patient’s spouse, direct blood relative or collateral blood relative within three generations, disabled or mentally disabled people cannot donate organs. 2. Generally speaking, one kidney is enough to meet the body’s needs. However, if you are unfortunate enough to suffer from trauma, kidney stones, tumors and other diseases in your future life, you will face greater surgical risks than normal people, and your only kidney may be forced to be removed, and your selfless dedication may lead to uremia. 3, foreign statistics, the mortality rate of kidney donors is about 0.03% (or three out of ten thousand), no statistics in China, but there are cases of death and other serious complications. 4.Your kidney is not guaranteed to live permanently in the recipient, and you should be able to accept this reality. The recipient should have the following considerations before deciding to have a relative living kidney transplant: 1. Living kidney transplantation is not the only option, hemodialysis, peritoneal dialysis and cadaveric kidney transplantation are all good alternatives. 2. Living kidney transplantation can also result in rejection and infection, leading to nephrectomy and death. Chronic rejection can also occur, leading to gradual loss of function of the transplanted kidney and a return to dialysis. 3.Despite advanced immunosuppressive drugs, it is not possible to absolutely avoid hyperacute rejection regurgitation (which can lead to removal of the transplanted kidney), even parents donating kidneys to their children cannot be an exception. 4. Although statistics show that the long-term survival rate of living relative transplantation is higher than that of cadaveric donor kidney, for individuals, the final survival rate is also affected by various factors such as the age of the donor kidney, the quality of the donor kidney, and the patient’s compliance after surgery. After careful consideration, please go to the local police station to issue a certificate of kinship and go to a notary public for justice, and bring both donor-recipient ID cards and hukou books to the hospital for HLA matching and comprehensive physical examination. After passing the hospital ethics meeting, you have to wait for the approval of the higher health administration department, and this time usually takes several months to wait. Finally, to ensure the safety of the donor recipient, please go to a large transplant center with transplant qualification for live kidney transplant. Kindly note that organ trading is illegal and organ donation by non-relatives is eliminated!