The common factors of closing right lower abdomen pain are appendicitis, intestinal tuberculosis, intussusception, etc. The causes are different and the treatments are different. Common treatments include medication and surgery. 1. Appendicitis: appendicitis is categorized into acute appendicitis and chronic appendicitis, the principle of appendicitis treatment is surgical removal of the appendix, which is the most effective way to cure appendicitis. The purpose of surgical treatment is to remove the diseased appendix and close the appendiceal bed to control the infection, the methods used are open appendectomy and laparoscopic appendectomy. 2. Intestinal tuberculosis: patients with intestinal tuberculosis need early, full, moderate and combined anti-tuberculosis treatment, commonly used drugs include isoniazid, rifampicin, ethambutol, streptomycin and so on. 3. Intussusception: If there is a combination of abdominal infection or systemic inflammatory response, patients can be treated with broad-spectrum antibiotics combined with anti-anaerobic drugs, such as amoxicillin, metronidazole and so on. If it is ileocecal type intussusception, early surgical treatment is needed. Symptoms of closing right lower abdominal pain should be promptly consulted to avoid delay.