Many patients with hepatitis B and hepatitis B cirrhosis feel good about themselves after taking antiviral drugs for a period of time with normal liver function and HBV-DNA turning negative. When they go to the hospital, doctors often recommend that they continue to use the medication, why is this? In other words, they cannot completely cure the disease. In other words, none of them can completely cure the disease. If the criteria for stopping the medication are met, premature discontinuation of the medication will only cause the disease to recur. Even if the so-called discontinuation criteria are met, there is still a relapse rate of about 30%. Secondly, if the discontinuation of oral antiviral drugs causes relapse, it is often necessary to intensify antiviral treatment to control the disease, which further increases the psychological and economic burden of patients. Again, relapse increases the mutation rate of the virus in the future, which makes multiple drugs ineffective and complicates clinical treatment.