A nodule on the liver that is hypoechoic with smooth margins is not necessarily cancer. Hypoechoic liver with nodules and smooth margins is a relatively common lesion, mainly caused by lesions in liver function, which may be tumor, but it may also be inflammatory lesions. As a kind of malignant tumor, liver cancer is divided into primary liver cancer and secondary liver cancer, which can not be directly diagnosed as cancer by one test alone. To diagnose whether it is cancer or not, you need to go to the hospital to do tumor marker test, puncture biopsy and so on to make a diagnosis. Nodules on the liver, hypoechoic, with smooth edges may also be fatty liver, viral hepatitis, etc. If it is fatty liver, it needs to be treated with medication, such as orlistat, metformin, resuvastatin, etc., and it can also be improved by improving dietary habits to alleviate the symptoms. In case of viral hepatitis, treatment such as antiviral is usually needed. Nodules found on the liver, hypoechoic, with smooth margins should be further improved with relevant examinations, such as enhanced CT of the liver, biopsy, etc., to clarify the cause of the disease and actively treat it.