Hashimoto’s thyroiditis combined with nodules, mostly proliferative benign nodules, the condition is usually not serious; if combined with thyroid cancer, the condition may be serious. Hashimoto’s thyroiditis with nodules is a common clinical thyroid disease, and the nodules are usually hyperplastic and benign. Patients with Hashimoto’s thyroiditis do not need treatment if they have normal thyroid function and no obvious discomfort. Patients with Hashimoto’s thyroiditis who develop hypothyroidism can be supplemented with levothyroxine tablets, and the condition is usually not serious. Some patients with Hashimoto’s thyroiditis may have thyroid cancer, which grows faster and can be diagnosed by ultrasound and puncture biopsy. It is recommended that patients seek timely medical treatment, improve the relevant examinations, and comprehensively assess the condition.