Subcutaneous penile hardness is generally referred to as penile sclerosis, a small number of patients may be self-treatment, but there is no self-treatment. It is recommended that patients go to regular hospitals to take medication, surgery and other treatments. Penile sclerosis has the possibility of self-healing, but there is no self-treatment way. Patients with penile sclerosis that cannot be self-treated can take levocanidin, vitamin E, colchicine, sildenafil, and medications such as cyproterone and tamoxifen under the guidance of a doctor. In addition, some patients can be treated with injections of calcium channel antagonists in the area of the sclerosis as prescribed by their doctor, such as diltiazem and verapamil. If sclerosis leads to penile curvature deformity, it needs to be treated with leucoplasty, leucoplasty, leucoplasty, leucoplasty, and penile support implantation. Penile sclerosis cannot be self-treated. It is recommended that patients go to regular hospitals in time, doctors will choose appropriate measures to treat according to the patient’s condition, and strive for early recovery.