High total bilirubin indicates liver cell damage or cholestasis, and high total cholesterol indicates the presence of chronic alcohol consumption, stress, or a combination of atherosclerotic heart disease and cholestasis. Bilirubin is a product of the breakdown and destruction of senescent red blood cells in the blood circulation in the monocyte-macrophage system of the liver, spleen and bone marrow. The normal value is 1.7 to 17.1 umol/L. Elevated total bilirubin is called occult jaundice if it is between 17.1 and 34.2 umol/L, and clinically visible jaundice can occur if it exceeds 34.2 umol/L. Elevated total bilirubin often indicates hepatocellular damage or cholestasis, and the elevated value can be used to determine the presence or absence of jaundice, the degree of jaundice and the cause of jaundice. The normal value of serum total cholesterol is 2.9-6.0 umol/L, and total cholesterol is elevated if it is greater than 6.0 umol/L. Elevated total cholesterol is affected by a variety of factors, which may be related to physiological causes such as long-term alcohol consumption, smoking, mental stress, etc., and also reflect the possible combination of atherosclerotic heart disease, cholestasis, hyperlipoproteinemia and other diseases. There are many reasons for high total bilirubin and cholesterol, and it is not possible to generalize what they are, so it is recommended to consult a doctor in time and standardize the diagnosis and treatment.