Hypoechoic nodule in the parenchyma of liver S6 segment generally refers to the presence of occupying lesions in the lower right posterior lobe of the liver during ultrasonography, which may be due to some tumor factors or non-tumor factors resulting in local abnormalities of the liver. 1. Malignant tumors suspected to be localized in the liver include primary hepatocellular carcinoma, intrahepatic cholangiocarcinoma, metastatic hepatocellular carcinoma, etc., which should be detected, diagnosed and treated early, and most of them should be resected by surgery. 2. Suspected benign liver tumors include hepatic hemangioma, hepatic cysts, etc. The causes are not clear, which may be caused by congenital developmental abnormality, bad life habits, hormone level disorders, etc. Most of the benign tumors don’t need special treatment, but regular review and follow up is required. 3. Suspected atypical hyperplasia nodule, due to inflammatory stimulation, vascular malformation and so on, may also be manifested as hypoechoic nodule. Further examination should be carried out to determine its benign or malignant nature, and standardized treatment should be carried out under the guidance of doctors.