Gastroscopy shows scattered white granular material in the esophagus needs further medical examination, such as inflammation should be acid-suppressing treatment; such as mycobacterial esophagitis should be antifungal treatment. 1. Mucosal hyperplasia caused by inflammation: chronic inflammation of the esophagus stimulates the mucosa and causes mucosal epithelial hyperplasia. Gastroscopy can see white granular material on the esophagus; if there is acid reflux, nausea, loss of appetite, it should be timely medical treatment, active symptomatic treatment, taking acid inhibitors, such as omeprazole and so on. 2. Mycobacterial esophagitis: mostly seen in patients with low resistance, such as diabetes, tumors, radiotherapy patients and immunosuppressants; in addition, there are also some patients with oral mycobacteria caused by swallowing. Usually apply antifungal drugs, such as fluconazole, voriconazole and so on. It is recommended that any discomfort should be timely medical consultation with a professional doctor for treatment, not blindly self-medication.