Leuprolide is usually given in 3 injections to shrink the uterus; the exact number of injections is related to the severity of the condition, individual’s constitution and other factors. Leuprolide is a gonadotropin-like drug that is clinically used for endometriosis, accompanied by symptoms such as heavy menstrual periods, lower abdominal pain, anemia, and low back pain; it is generally recommended that patients receive ultrasound after 3 injections to observe the recovery of uterine lesions. Common adverse effects of leuprolide include gastrointestinal symptoms, such as nausea, vomiting and loss of appetite, as well as urinary symptoms, such as leukorrhea, non-menstrual bleeding, blood uric acid and urea nitrogen rise, etc. It is contraindicated in patients with endometriosis and uterine fibroids. Clinical application of leuprolide has certain risks, patients need to be used under the guidance of a specialist.