For hepatitis B patients, routine hepatitis B tests are essential. Many patients do not understand the results of hepatitis B tests and are particularly nervous when they find that the test results show high bilirubin, wondering what high bilirubin means, whether high bilirubin means liver damage, and whether high bilirubin is related to their condition. Bilirubin is one of the liver function test items, which is mainly used to reflect the metabolism of the liver, and can also indirectly reflect whether there is damage to liver cells. Bilirubin is also present in normal blood, ranging from 5 to 20.8 μmol/L. However, if a patient’s liver function test reveals a bilirubin concentration much higher than the normal bilirubin value, the patient will most likely have a yellow face, yellow urine or yellow sclera of the eyes. Bilirubin is an important basis for judging jaundice, but it is not a sensitive indicator of liver damage. Only when bilirubin is significantly elevated does it indicate serious liver cell damage or cholestasis, It is not a case of “mild damage if it is slightly elevated” or “severe damage if it is severely elevated”. Sometimes, when a patient’s liver damage is so severe that he or she tends to have cirrhosis, the bilirubin may not be elevated, and in the case of jaundice, the bilirubin is greatly elevated, but the damage to the liver cells is not severe. Usually, the high bilirubin found in the examination of hepatitis B patients is mostly a symbol of the deterioration of the development of the disease. Therefore, experts suggest that patients with hepatitis B should contact their doctors in a timely manner to clarify the specific cause of high bilirubin. If it is caused by the deterioration of the patient’s condition, the increased damage to the liver, the abnormal liver function, and the weakened transformation and metabolism of bilirubin by the liver, they should actively cooperate with their doctors for treatment to prevent the continuous development and deterioration of their condition.