Anal atresia has a complex etiology so far, there are several possibilities, considerations related to the family, genes, i.e., genetic related factors, such as genetic mutations may cause anal atresia, the rectum and anus in the early embryonic period are fused together, by the 8th-9th week of the embryo, the rectum extends to form the anus, and in the process of extension, if the mother is subjected to radiation from rays or toxic or harmful substances, During the process of extension, if the mother is exposed to radiation or toxic or harmful substances, it may cause the extension of the rectum to stop in the middle of the process, resulting in the anus not being formed and anal atresia after birth. Depending on the time of cessation of extension, the anus may end up being high anus if it is relatively early, or low anus if it is relatively late, simply because a layer of skin is not strung underneath. Generally the results of low anoikis surgery are better, while high anoikis surgery can be less effective. Overall, the current causes of anal atresia in anoikis can be summarized as hereditary factors, familial factors, genetic mutations, maternal exposure to radiation and stimulation by toxic and hazardous substances, which at this particular time can cause the process of rectal extension to stop halfway through the process, leading to an abnormal anus, and thus anal atresia.