Some clinical investigations show that after applying chemotherapeutic drugs, the one-year survival rate of advanced esophageal cancer after chemotherapy reaches 36.3%. However, the specific survival time is related to various factors such as individual physique, disease progress, treatment sensitivity and so on. Generally speaking, if multiple lymph node metastases have already appeared in the advanced stage of esophageal cancer, chemotherapy, radiotherapy, immunotherapy, surgery and other means of treatment can be used according to the specific conditions of patients. The effective rate of chemotherapy is about 20%-60%. If chemotherapy is not effective, the median survival period is only 5-10 months, and the 5-year survival rate is only 5%. 1-year survival rate and 5-year survival rate are commonly used in clinic to roughly assess the survival of tumor patients. How long can advanced esophageal cancer patients live after chemotherapy depends on whether they follow the doctor’s instructions, maintain healthy diet and living habits, and keep a positive and optimistic mindset during the treatment period in order to achieve better therapeutic effects.