If an acute abscess develops in the sacrococcygeal region, if it is secondary to a surface infection, such as a sebaceous cyst with infection, the causative organism is usually a Gram-positive coccus, and penicillin or first-generation cephalosporin antibiotics are the clinical first choice for treatment, usually by oral or intravenous injection. If it is secondary to the rectal canal, because the intestinal tract usually contains gram-negative bacilli, then the choice of antibiotics should be selected from the second generation of cephalosporin antibiotics, can take into account both gram-positive cocci and gram-negative bacilli to kill, usually use the second generation of cephalosporin antibiotics, intravenous injection to obtain a cure.