Headache powder contains three main ingredients: acetaminophen, aspirin and caffeine. Acetaminophen and aspirin are non-steroidal anti-inflammatory drugs, with the main role of antipyretic and anti-inflammatory effects, mainly used for toothache, joint pain, headache, fever, etc.. The main effect of caffeine is to improve the spasm state of blood vessels, thus playing a role in relieving headaches. The combined application of the three components can play a role in relieving headaches, and the drug should not be used for a long time. Acetaminophen and aspirin have an irritating effect on the gastric mucosa, and long-term application may cause gastric bleeding, and may cause liver and kidney function damage. The long-term application of caffeine has an addictive effect, and it is best to go to the hospital for further examination to confirm the diagnosis and find out the cause of the headache.