Osteomalacia of the knee can be relieved by oral anti-osteoporosis drugs, nutritive cartilage drugs, and non-steroidal anti-inflammatory drugs. 1. Anti-osteoplasia drugs: Osteoplasia is caused by degeneration of the knee joint, early oral anti-osteoplasia drugs can be taken, such as anti-osteoplasia pills or bone fairy tablets to slow down the development of osteoplasia, and at the same time to reduce the weight of the knee joint. 2. Nutritional cartilage drugs: you can apply nutritional cartilage drugs, such as glucosamine sulfate capsule, which can promote the synthesis of polyglucosamine, nutritional cartilage, and relieve joint pain. 3. Non-steroidal anti-inflammatory drugs: such as Nimesulide or Aceclofenac tablets for anti-inflammatory and pain relief treatment. Medications can relieve joint pain caused by osteomalacia of the knee, and for more serious osteomalacia that affects joint activity, knee replacement surgery is needed. When the symptoms of osteomalacia of the knee are serious, you should go to the hospital in a timely manner, complete the relevant examinations, and follow the doctor’s instructions for standardized treatment after a clear diagnosis, do not blindly use medication on your own, so as not to delay the condition.