Isosorbide nitrate does not need to be taken for a long period of time in patients who are completely asymptomatic. Nitroglycerin can be used as a backup, and if there is a recurrence of symptoms, consult the doctor in time to adjust the treatment. Isosorbide nitrate, as a drug for the treatment of coronary heart disease, can relax vascular smooth muscle, causing vasodilation, thus reducing vascular resistance and achieving the purpose of preventing atherosclerosis. Clinically, it is mainly used to relieve the symptoms of angina pectoris and myocardial infarction. For patients with symptomatic coronary heart disease, the dosage form and dosage of nitrate drugs can be adjusted according to the frequency and time of symptom occurrence. For patients with coronary artery disease, the use of such drugs can also be suspended if there are no symptoms of chest pain after the condition is stabilized. However, there are some patients who have obvious headache, dizziness, fatigue, nausea, vomiting, diarrhea, etc. after taking the drug, and even cannot tolerate it, and there is no way to insist on using it. In addition, a small number of patients will also cause dyspnea, loss of consciousness and anxiety, once the above adverse reactions occur, patients should stop taking it immediately and seek medical attention. In addition, patients with coronary heart disease can be taken before or after meals, depending on the individual situation; and patients with a certain degree of drug resistance to the drug, it is recommended to try to take in the morning on an empty stomach. Therefore, patients with recurrent coronary heart disease can apply these drugs for long-term vasodilator treatment; if the condition is stable without any symptoms, the use of patients can be suspended. In terms of long-term safety, isosorbide nitrate is also relatively safe. The use of drugs need to follow the doctor’s instructions.