A pimple that won’t go away is considered to be nodular acne, boils, sebaceous cysts, etc., which can be treated with medication, physical and surgical treatments. 1. Nodular acne: The onset of the disease is related to abnormal androgen levels and keratinization of the sebaceous gland ducts of the hair follicles, causing dark red nodules on the skin, resulting in a pimple that won’t go away. Patients can follow the doctor’s instructions to apply adapalene gel, tazarotene cream and other drugs, and with photodynamic therapy, which can act directly on the follicle sebaceous gland area, to help the condition recover. 2. Boils: acute suppurative infections that occur in hair follicles and their surrounding tissues. The initial manifestation is simple follicular pimples, and then become pustules, accompanied by redness, swelling, heat and pain and other symptoms. At this time, you can use topical mupirocin ointment, fusidic acid cream. If necessary, oral antibiotics such as amoxicillin capsules. 3. Sebaceous cysts: they are retention cysts formed after the sebaceous gland excretory ducts are blocked, resulting in the appearance of skin swellings, the growth rate is also slow, and the appearance of a pimple has not been eliminated hard. Patients can choose to do cyst excision surgery treatment, can directly remove the cyst. A pimple has not been eliminated hard also consider sebaceous gland ectasia and so on, it is recommended that patients go to the hospital in time, clear cause of the disease for symptomatic treatment. The above drugs should be used in accordance with medical advice.