The main adverse reactions of fenofibrate taken for a long time are symptoms of the gastrointestinal tract, such as abdominal discomfort, diarrhea, constipation, and skin rash are most common. Neurological adverse reactions include weakness, headache, loss of libido, impotence, and even dizziness and insomnia. Long-term application of fibrates may induce chronic hepatitis similar to type I autoimmune hepatitis, which can gradually recover after stopping the drug. Fenofibrate may cause a mild increase in glutamic oxalacetic transaminase and glutamic alanine transaminase, and may occasionally cause muscle damage. Fenofibrate can enhance the activity of lipoprotein esterase, accelerate the catabolism of very low density lipoprotein, and inhibit the synthesis and secretion of very low density lipoprotein in the liver. Fenofibrate mainly reduces triglycerides, is well tolerated clinically, easy to take, and has a half-life of 20 hours.