Duodenal mesenchymal tumor belongs to the junctional tumor, may be benign tumor or malignant tumor, in the clinic can be through the endoscopic ultrasound puncture biopsy, and puncture biopsy has a high sensitivity, is conducive to the diagnosis of the disease, but can not be given percutaneous puncture biopsy. 1. Endoscopic puncture biopsy: the diagnosis of duodenal mesenchymal tumors can be made by color ultrasound, CT and other imaging examinations and tumor marker examinations for preliminary screening. However, the diagnosis needs to be confirmed by pathological examination, and the main way in clinic is to perform puncture biopsy on the lesion tissues by using a long and thin needle under the positioning of endoscope. 2. Percutaneous puncture biopsy: Because duodenal mesenchymal tumors have the possibility of malignant tumors, in the process of percutaneous puncture biopsy, it may lead to abdominal implantation and metastasis of the lesion cells, so it is not possible to perform percutaneous puncture biopsy. It is recommended to go to the hospital, improve the auxiliary examination, in order to clarify the condition, and then give the relevant examination and treatment by the professional physician, so as to avoid delaying the condition.