When there is pain in the lowermost part of the right lower rib cage. First of all, patients with pleurisy can usually have pleuritic chest pain on the affected side, i.e., when the patient coughs or sneezes, the pain in the chest and ribs is significantly increased, and the nature of the pain is mostly burning or dull pain, and a chest X-ray or CT examination is needed at this time. Secondly, some lung diseases can also cause pain in the affected side of the chest and ribs, such as pneumonia, where the inflammation is close to the periphery of the lung, resulting in significant local chest pain. In addition, attention should be paid to the presence of abdominal diseases, such as cholecystitis, acute pancreatitis, gallbladder stones, etc. Therefore, when pain occurs at the lower right rib cage, appropriate tests should be completed to clarify whether there is any pain caused by diseases of the lung, pleura, chest wall, or abdominal cavity.