Delayed reaction after craniotomy may be normal if it occurs in the short term after surgery; however, if it occurs for a long period of time after surgery, it is considered abnormal and should be analyzed in conjunction with other accompanying symptoms. If the current interval after craniotomy is relatively short, the patient’s unresponsiveness occurs in the short-term postoperative period, which may be normal and is usually related to the reaction to anesthetics, and when the anesthetic effect is completely eliminated, the symptom will gradually reduce and return to normal. If the time from the craniotomy is relatively long, and the patient has a prolonged period of unresponsiveness, it is accompanied by symptoms such as dizziness, headache, trance, and impaired consciousness, then it is considered to be abnormal, and it is mostly related to the increase in intracranial pressure that occurs after the craniotomy, which results in intracranial pressure edema, hypoxia, cognitive decline, and other factors. If patients are found to be unresponsive after craniotomy, they should seek medical attention and analyze the cause of the disease through the guidance of professional physicians before carrying out formal treatment.