In the clinic, if the patient has duodenal bulb cream ulcer, it is recommended that the patient take oral omeprazole and other drugs for treatment, and if there is Helicobacter pylori infection, it is also necessary to give quadruple eradication of Helicobacter pylori treatment. Because the occurrence of duodenal bulb cream ulcers is mainly related to the patient’s excessive gastric acid secretion and Helicobacter pylori infection, the treatment of duodenal bulb cream ulcers is mainly through the inhibition of gastric acid secretion and the eradication of Helicobacter pylori infection, omeprazole as a proton pump inhibitor has a fast onset of action, but also in a short period of time to rapidly elevate the patient’s gastric pH value, which can quickly stabilize the acid-sensitive antibiotics, and thus strengthen the The bactericidal effect of antibiotics that are unstable in an acidic environment provides an ideal PH value action environment for antibiotics such as amoxicillin and metronidazole, which can play a good role in killing Helicobacter pylori. In the clinic, the quadruple combination of drugs, for Helicobacter pylori infection and the combination of excessive gastric acid secretion in patients with duodenal bulb frosted ulcers, has a very good therapeutic effect, and is worthy of clinical promotion and application.