At 3 o’clock in the morning, it should be the time when the stomach and duodenum have been emptied, which means that it is difficult to wake up in the middle of sleep, indicating that the degree of this difficulty should be quite large. In general, this kind of hunger pain is common in duodenal bulb ulcer, inflammation of the duodenum, often it is with Helicobacter pylori infection, drinking alcohol, eating improperly and so on are related. If it is duodenal bulb ulcer, it is more serious, and in severe cases, bleeding, perforation, narrowing of the digestive tract and so on will occur. So it is recommended to go to the hospital formal check gastroscopy, it is best to check the Helicobacter pylori test, if it is a problem in this area, timely and formal examination and treatment, the prognosis is still very good, do not insist on your own at home, so as not to delay the condition, the consequences are still more serious.