An estimated glomerular filtration rate of 80-120 ml/min is considered normal. Usually, the glomerular filtration rate of men is slightly higher than that of women. Generally, the glomerular filtration rate of human body starts to decline after the age of 40, generally about 10% every 10 years, and about 40% after the age of 80, but this generally does not affect the normal life of people. Glomerular filtration rate refers to the flow of plasma through the glomerulus per unit of time. This value cannot be measured directly, but can only be estimated by the renal clearance of markers such as blood creatinine or the clearance of plasma. The glomerular filtration rate of patients with chronic kidney disease decreases gradually as the disease progresses. When the glomerular filtration rate is below 15 ml/min or less, it is mostly considered to be at or near uremia. At this period of time, renal replacement therapy is usually needed, and the most common methods are hemodialysis and peritoneal dialysis treatment. If the patient has any discomfort or abnormal glomerular filtration rate, it is recommended to go to a regular hospital for consultation and targeted treatment under the guidance of a physician.