1, hypotensive drugs These drugs are most closely related to sexual dysfunction such as hypersexuality, loss of orgasm and impotence. If the daily dosage of guanethidine is above 25 mg, most male patients will have adverse reactions such as impotence, delayed ejaculation or inability to ejaculate, while female patients will show a lack of vaginal lubrication and decreased libido. Methyldopa can cause decreased libido or impotence in men and amenorrhea, overflow, decreased sexual arousal and loss of orgasm in women, although the daily dosage is less than 1 gram. Risperdal can also reduce libido, impotence and even induce depression in most male patients, so patients with a history of depression should not use Risperdal. In addition, colistin, hydrazinepyridazine, mecamylamine, prazosin, etc. can also cause sexual dysfunction. 2, anti-cardiac drugs used for congestive heart failure digitalis, digoxin, strong mind, etc., can cause men with low sexual function or impotence. The treatment of heart rhythm disorders, the daily dosage of up to 40-320 mg, is very likely to cause hypersexuality and impotence. 3, diuretics Androstadienone has anti-androgenic effect, if used for a long time, it can cause hypogonadism or impotence in men, menstrual disorders, amenorrhea, and even stop ovulation in women. Tachyphylaxis and diuretic can induce hypokalemia and then impotence, but it can be changed after supplementing potassium salt. 4.Anti-cancer drug Bacitracin (Marilan) can induce testicular atrophy in men and amenorrhea in women. Cyclophosphamide can cause sperm and semen deficiency in men and amenorrhea or menstrual disorders in women. 5, antipsychotics chlorpromazine daily dosage of up to 400 mg, will cause male patients with reduced libido, impotence or testicular shrinkage, female patients with reduced libido or lack of libido. Lithium carbonate can make some male patients unable to ejaculate or develop impotence. Long-term application of haloperidol can cause impotence in male patients and menstrual disorders and lack of libido in female patients. 6, sedative-hypnotic drugs sedative drugs such as Valium, Anin and luminal, amytal, quick sleep and other hypnotic drugs after long-term use, can cause male patients to experience a loss of libido, impotence or loss of orgasm. 7, hormones Estradiol and ethinyl estradiol used in men with prostate cancer can cause impotence and impaired ejaculatory function. Chlormadinone can cause decreased libido, impotence or orgasm in men. If large amounts of methyltestosterone and testosterone propionate are applied for a long time, they can cause testicular atrophy, reduce sperm and semen, and affect sexual desire. Prednisone (prednisone) can affect spermatogenesis at a daily dose of 30 mg. Hydrogenated prednisone can lead to semen deficiency. 8, sulfonamides Willow nitrogen sulfadiazine pyridine will cause semen deficiency, sperm reduction. 9, gastrointestinal antispasmodics Atropine sulfate, scopolamine, etc., can make male patients impotent and female patients with reduced sexual excitement. 10.Anti-allergic drugs Paracetamol, Anchormin, Fenagine, etc., can lead to the reduction of male and female sexual function. 11, in addition, dysentery, anti-inflammatory pain, stomach, eugenol and cimetidine, promethazine, etc., can also cause male and female sexual dysfunction. However, after 3-6 months of discontinuation, all can gradually return to normal.