Connective tissue disease is a disease in which the connective tissues of the body are involved. In fact, it is a collective term for the early or still difficult to classify stages of rheumatic immune diseases. It is generally thought to be related to genetic immune abnormalities, and viral infections. Most of the connective tissue diseases have autoantibodies, and can involve multiple systems, commonly systemic lupus erythematosus and rheumatoid arthritis, dry syndrome; lupus erythematosus patients are mostly women, the face can form butterfly-shaped erythema, may be complicated with nephritis, joint pain, oral ulcers; rheumatoid arthritis is mainly manifested in the limbs of the joints of the small joints swelling and pain; dry syndrome, the main symptoms are the appearance of the mucous membranes of the oral cavity, the mucous membranes of the eyes, such as dry discomfort symptoms. Dry syndrome, the main symptom is the appearance of oral mucosa, mucous membrane of the eyes and other symptoms of dry discomfort.