Calf acid oral medication should be identified before the cause, according to different reasons to choose the right drug, common causes are strenuous activities, varicose veins in the lower limbs, lumbar disc herniation, etc., the drugs include non-steroidal drugs, vasodilators and muscle relaxants. 1. Strenuous activities: running, going up and down the stairs and other strenuous activities cause calf soreness, you can take oral non-steroidal drugs such as celecoxib, meloxicam and so on. 2. Varicose veins in lower limbs: vasoprotective drugs can be given to improve microcirculation, such as Diosmin, etc. 3. Lumbar disc herniation: compression of the sciatic nerve causes calf soreness, you can take non-steroidal drugs such as ibuprofen, celecoxib, etc., as well as muscle relaxants such as chlorzoxazone, etc., to prevent spasms. Cause calf soreness may also have other reasons, it is recommended to go to the hospital in a timely manner, improve the examination, clarify the cause of the disease, standardized treatment under the guidance of the doctor, the above drugs can not be taken on their own.