Nursing care for COPD is divided into acute exacerbation nursing care and stabilization nursing care, and the focus of nursing care is different in different stages. For patients with acute exacerbation of COPD, they should be actively sent to the hospital and treated with necessary bronchodilators, antibiotics, glucocorticosteroids and expectorant drugs by professional respiratory doctors, and low-flow oxygen inhalation will also be given to the patients. In the process of nursing care, it is necessary to pay attention to whether the patient’s oxygen nasal catheter is dislodged and whether the oxygen concentration is maintained appropriately, generally controlling the oxygen concentration at 28%-30%, and it is also necessary to keep the patient’s sputum discharged in a timely manner, to prevent sputum from stagnating and choking sputum coughed up into the oral cavity back into the airway. For the care of stabilized COPD patients, first of all, we need to educate and persuade patients to quit smoking, and at the same time to ensure that the patient’s living environment is good, to avoid the presence of excessive dust or irritating gases in the living environment. In addition, in addition to supervising the patients’ rational and standardized use of medications, long-term home oxygen therapy should be adhered to, which has a certain effect on improving the patients’ quality of life and increasing the survival rate.