Azithromycin is a prescription drug with a pharmacological mechanism of action as a bacteriostatic agent, which has an insecticidal effect on protozoa. For example, cough caused by mycoplasma or chlamydia infection in children in spring and autumn is better treated by azithromycin. If administered by oral administration, bioavailability is better and once a day is sufficient; if administered by intravenous administration, it needs to be changed to oral medication after 1-2 days and continuous intravenous administration is not recommended. Because the oral formulation of azithromycin has sufficient bioavailability to meet the demand, injectable administration should be an option only in case of fasting. Clinical recommendations for the use of antimicrobial drugs require strict indications for administration to avoid bacterial resistance caused by blind dosing and unnecessary risks to patients.