Hepatitis B penta test 15 positive indicates that the replication of hepatitis B virus is weak, low infectiousness, if the liver function is normal, regular review can be done without special treatment, if the liver function is abnormal, drug treatment should be used such as using liver-protecting drugs, such as glucuronolactone and so on. Hepatitis B five items include surface antigen, surface antibody, e antigen, e antibody and core antibody. By testing and analyzing these five items in the blood, we can know whether we are infected with hepatitis B virus and whether we are hepatitis B virus carriers, which is of great significance to the diagnosis of hepatitis B and the determination of the therapeutic efficacy. The first and fifth positive items suggest that the replication of hepatitis B virus is weak and the infectiousness is low. If the liver function is normal, regular review is enough and no special treatment is needed. If the liver function is abnormal, you can use antiviral drug entecavir and interferon as prescribed by the doctor, and liver-protecting drugs such as glucuronolactone and liver-protecting tablets. Hepatitis B patients should pay attention to avoid smoking and drinking in daily life, avoid staying up late, overeating and so on, balanced diet, reasonable exercise. After infected with hepatitis B, they should consult the doctor in time and have regular checkups.