Contraceptive drugs may lead to the following diseases if taken for a long time: 1. endocrine disorders, which may be manifested as menstrual disorders or irregular vaginal bleeding. 2. reduced menstrual flow, because long-term use of short-acting contraceptives may cause the endometrium to become thinner and therefore lead to reduced menstrual flow. 3. damage to liver and kidney function, because short-acting contraceptives are a combination of estrogen and progestin, and most of the drugs are detoxified by the liver and excreted by the kidneys after being eaten into the body. Most of the drugs are detoxified by the liver and excreted by the kidneys, which may lead to a certain impact on liver and kidney function if applied for a long time. It is recommended to do the corresponding examination before taking oral short-acting contraceptives to know whether there are contraindications, and it is also recommended to go to the hospital for regular review after taking the pill.