The wound infection has been using anti-inflammatory drugs, many kinds, but they do not work, why? My diabetic foot treatment specialist reminds us that this situation is likely to get worse if we use medication blindly! In retrospect, many of the podiatric patients seen in our diabetic foot treatment center have a history of topical use of medications, and without exception, they have not improved, but have instead faced serious encounters with toe amputation or amputation. Some patients even lasted for many years before and after without a cure, causing a great blow to their lives, physically and psychologically. Why is this so? Because even for some effective topical drugs, before using the drug, the wound must be treated traumatically to clean up the necrotic inactive skin, muscles, etc. so that the drug (provided it is an effective drug) will be in full contact with the healthy wound to achieve the effect. On the contrary, the presence of inflammatory tissues hinders the absorption of the drug effect and the infection further erodes the healthy tissues, which will definitely become more and more serious. At the same time, we should know that foot ulceration is a complication of diabetes, but it is not simply the presence of a wound. Many patients have cardiovascular insufficiency, kidney disease, and other particularly complex physical conditions, all of which may directly or indirectly affect the direction of trauma development. Medication alone, if used incorrectly, may also aggravate the infection, accelerate the speed of ulceration and aggravate the condition, so be especially cautious. In short, diabetic foot is a very dangerous disease, and it is not uncommon for someone to have a rapid deterioration of the condition and nearly be amputated because of the indiscriminate use of drugs to dress the wound on the foot. I suggest that we should go to a regular specialist hospital for timely treatment to avoid the irreversible consequences of delaying the disease due to indiscriminate use of drugs.