The sore throat in the morning, swallowing pain, may be acute pharyngitis, acute epiglottitis, pharyngeal tumors and other causes, according to the specific disease, comply with the doctor’s instructions oral medication, nebulizer inhalation, biopsy and pathological examination through surgery or radiotherapy treatment. 1. Acute pharyngolaryngitis: it usually starts rapidly and is related to catching cold at night, manifesting as sore throat, hoarseness, fever and cough. It can be treated with anti-infection by taking Roxithromycin dispersible tablets and Cefixime dispersible tablets as prescribed by the doctor. 2. Acute epiglottitis: Typical symptoms are sore throat after waking up in the morning, stuffiness, and pain when swallowing saliva. Patients can follow the doctor’s instructions oral amoxicillin, cefadroxil and other antibiotics, and with the inhalation of budesonide suspension for nebulizer treatment, if accompanied by local abscess formation should be incision and drainage of pus, if necessary, the need to establish an artificial airway. 3. pharyngeal tumor: pharyngeal tumors can cause sore throat and swallowing pain in the morning, which is common in middle-aged and old-aged patients, and require laryngoscopy, tracheoscopy and other tests to clarify the condition, and biopsy pathology to confirm the diagnosis, and after diagnosis, surgery or radiotherapy can be carried out. There are many causes of sore throat and swallowing pain in the morning, patients should go to the hospital in time, clear cause of the correct treatment under the guidance of the doctor.