The difference between Penicillin V potassium tablets and Roxithromycin is mainly manifested in the mechanism of action, indications, contraindications and other aspects. 1. Mechanism of action: Penicillin V potassium tablets belong to penicillin antibiotics, the mechanism of action is to inhibit the synthesis of bacterial cell wall, so as to achieve antibacterial effect. The mechanism of action of Roxithromycin is to inhibit the synthesis of ribosomal protein to achieve antibacterial effect. 2. Different indications: penicillin V potassium tablets is a penicillin drug, mainly used for a variety of sensitive bacteria caused by mild and moderate infections. For example, tonsillitis and pharyngitis caused by cocci, bronchitis and pneumonia caused by pneumococcus. Roxithromycin is a macrolide antibiotic, commonly used in pharyngitis and tonsillitis caused by Streptococcus pyogenes, sinusitis and otitis media caused by sensitive bacteria. 3. Contraindications: People who are allergic to penicillin are forbidden to take Penicillin V Potassium Tablets, and a penicillin skin test must be conducted first when taking the drug. People with hepatic insufficiency and renal insufficiency, etc. should use Roxithromycin with caution. Pregnant women and lactating women should be cautious of using Penicillin V Potassium Tablets and Roxithromycin, for the general population, taking drugs should be under the guidance of professional doctors, do not take it on your own, so as not to cause adverse effects on the body. If uncomfortable symptoms occur, you should seek medical advice in time.