A painless, itchy, soft, fleshy growth next to the anus may be due to external hemorrhoids, acromegaly and other diseases. 1. External hemorrhoids: the etiology of this disease is not clear, may be due to prolonged standing and sitting, improper diet and other factors leading to the emergence of substantial venous masses below the dentate line of the anal canal. Patients can generally follow the doctor’s instructions to use hemorrhoidal fast Ning tablets, hemorrhoidal suppositories and other drugs for treatment. For the more serious patients, can take thrombosed external hemorrhoid stripping surgery and other surgical methods for treatment. 2. Acute warts: usually due to human papillomavirus infection caused by sexually transmitted diseases, often preferred in the genitals and perianal, its clinical symptoms are mostly manifested as superfluous organisms. It is recommended that the patient timely medical examination, and under the guidance of the doctor to use the tincture of onychomycosis, imiquimod cream and other drugs for treatment, if necessary, can be taken to surgery or laser treatment. The patient appeared next to the anus grew a painless and itchy soft flesh, may also be related to sebaceous cysts and other diseases, with a symptom can not determine the cause of the disease, it is recommended to go to the hospital in a timely manner for further examination, a clear diagnosis, and give treatment as soon as possible.