Drinking alcohol after taking cephalosporin can cause a disulfiram-like reaction in severe cases, even life-threatening. Drinking alcohol after taking cephalosporins, cephalosporins will have a disulfiram-like reaction with ethanol in alcohol, and the enzyme acetaldehyde dehydrogenase in the body related to the metabolism of alcohol catabolism will be interfered with, which will make acetaldehyde in the blood accumulate excessively, thus causing the manifestation of poisoning. Mild symptoms may be manifested as facial flushing, headache, nausea, chest tightness, palpitations; in severe cases, tachycardia, drop in blood pressure, respiratory distress and even death may occur. Cephalosporins such as cefazolin, ceftriaxone, cefoperazone, cefpiramide, etc., can cause disulfiram-like reactions, of which cefoperazone is relatively the most sensitive and most likely to cause disulfiram-like reactions. Therefore, it is recommended that you do not drink alcohol after taking cephalosporin, and if you do, you should consult a doctor as soon as possible for standardized diagnosis and treatment.