High-grade neoplasia is usually likely to become carcinoma or carcinoma in situ, but the exact number of years is not easy to determine, it may be 3-5 years or longer. Generally, high-grade tumor is determined by biopsy pathology, but sometimes, because of the small size of the tissues taken, cancer may have already occurred. Therefore, once high-grade tumor is found, it is possible to recommend surgery for radical treatment first, such as high-grade tumor in the stomach, which may be due to the small biopsy tissue of gastroscopy, and then the test result is high-grade tumor, but in reality, there is already early cancer, at this time, it may be better to do radical treatment of gastric cancer and resection of most of the stomach, and the postoperative pathology is the basis of diagnosis, and also to avoid further cancer. The post-operative pathology is the basis for diagnosis and to avoid the possibility of further cancer.