Newborns with total bilirubin of 328μmol/L at 7 days and high jaundice index are considered pathologically jaundiced, and most likely require hospitalization, but the final treatment plan should be decided after doctor’s diagnosis. The normal neonatal jaundice index, i.e. serum bilirubin value, does not exceed 51.3 μmol/L. The highest jaundice index in the body of a newborn after 4 days does not exceed 171-205 μmol/L, and even in preterm infants, the jaundice index should not exceed 256.6 μmol/L. The total bilirubin of 328μmol/L in 7-day-old newborns, which is beyond the normal standard range, is considered to be pathological jaundice. There are many causes for this condition, and it is highly probable that the cause of the condition will need to be found in the hospital and hospitalized to receive treatment, but the specifics of the condition should be confirmed after diagnosis by a doctor. High total bilirubin in newborns, if serious, may lead to bilirubin brain damage, residual hearing impairment, etc. When high total bilirubin is found in newborns, attention should be paid to it and active treatment should be carried out under the guidance of the doctor, so as to avoid missing the time for treatment.